Study of 4-,5- and 7-day pantoprazole quadruple therapy regimens in the treatment of Helicobacter pylori Infection
- VernacularTitle:不同疗程四联疗法根除幽门螺杆菌的疗效观察
- Author:
Meihua CUI
;
Hong WEI
;
Xiaoyu LI
;
Fulian HU
- Publication Type:Journal Article
- Keywords:
Gastritis;
Helicobater pylori;
Pantoprazole;
Short-term quadrual regimen
- From:
Clinical Medicine of China
2008;24(8):782-784
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of pantoprazoh based short-term quadruple regimens in the treatment of Helicobacter pylori (H. Pylori) infection for 4 days,5 days or 7days. Methods 166 patients with H. Pylori associated severe gastritis were randomly divided into pantoprozole quadruple regimens of 4-day group (n =61) ,5-day group (n = 54) or 7-day group (n = 51). The regimen was pantoprazole 40 mg,bismuth potassium citrate 220 mg,elarithromycin 250 mg and amoxicillin 1 g twice daily. The patients received pantoprazole for 1 week, bismuth potassium citrate for 2 weeks,clarithromycin and amoxicillin for 4 days,5 days or 7 days respectively. The H. Pylori eradication and symptomatic relief was determinded by 13C-UBT at least 4 weeks after the therapy. Results The H. Pylori eradication rates of 4-day,5-day or 7-day panteprazole quadruple regimens were 73.8% (45/61) ,75.9% (41/54) and 80.4% (41/51) respectively. The pain relief rates were 82.4% (42/51) ,85.1% (40/47) and 88.9% (40/45) in 4-day,5-day and 7 day group. Conclusion The 4-day and 5- day pantoprazoh based quadrual therapy is a short- term, effective, safe and lower therapeutic- cost regimen for H. Pylori eradication.
