Change of T lymphocyte subsets and their different apoptosis in acute pancreatitis
- VernacularTitle:急性胰腺炎病人T淋巴细胞亚群改变与差异性凋亡
- Author:
Li KOU
;
Shengyi YOU
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
T lymphocyte subset;
Apoptosis;
Immune function
- From:
Chinese Journal of Hepatobiliary Surgery
2008;14(8):569-571
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic change and different apoptosis of T lymphocyte subsets in patients with acute pancreatitis.Methods Forty-four patients with MAP and 32 with SAP were enrolled in this study.Blood samples were collected on the lst,3rd and 7th d after onset.T lymphocyte subsets and their apoptotic rate were determined by flow cytometry.Results Compared with the control group and MAP group,CD4+ T lymphocytes and the ratio of CD4+/CD8+remarkably decreased while the apoptotic rate of CD4+ T cells significantly increased in patients with SAP.However,there was no marked difference in apoptotic rate of CD8+ T cells among different groups.Conclusion The different apoptosis of T lymphocyte subsets in AP,especially in SAP,results in severe and sustained cellular immune suppression.
