Preventive chemotherapy for hepatocellular carcinoma exceeding Milan criteria after fiver transplantation
- VernacularTitle:超出Milan标准肝癌肝移植患者术后预防性化疗的价值
- Author:
Zheng WANG
;
Jia FAN
;
Jian ZHOU
;
Zhiquan WU
;
Shuangjian QIU
;
Xiaowu HUANG
;
Yao YU
;
Jian SUN
- Publication Type:Journal Article
- Keywords:
Liver cancer;
Liver transplantation;
Preventive chemotherapy
- From:
Chinese Journal of Digestive Surgery
2008;7(4):268-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of preventive chemotherapy for hepatocellular carcinoma (HCC) exceeding Milan criteria after liver transplantation. Methods The clinical data of 243 patients who had undergone orthotopic liver transplantation for HCC exceeding Milan criteria from April 2001 to July 2007 were retrospectively analyzed. Of all patients, 162 received preventive chemotherapy after transplantation. Results The 1- and 3-year survival rates and disease-free survival rates were not statistically different between patients who had received chemotherapy (78.5%, 63.7% ; 76.8%, 52.5% ) and those without chemotherapy (56.6%, 39.1%; 69.3%, 64.7% ) (X2 = 3.084, 0.444, P > 0.05). Cox regression analysis demonstrated that postoperative chemotherapy was not an independent factor affecting the survival rates of HCC patients without vascular invasion, but an independent factor affecting the survival rates of HCC patients with vascular invasion. Conclusions Early preventive chemotherapy could obviously increase the survival rate and delay the tumor recurrence of patients with HCC exceeding Milan criteria, especially for HCC patients with vascular invasion.
