Correlation between polymorphism of apolipoprotein E gone and electroencephalogram after mild/moderate traumatic brain injury
- VernacularTitle:载脂蛋白E基因多态性与轻-中型脑损伤急性期脑电图改变的相关性
- Author:
Xuzhi HE
;
Xiaochuan SUN
;
Wei DAN
;
Fuying LIU
;
Yong JIANG
;
Jian RUAN
- Publication Type:Journal Article
- Keywords:
Apolipoprotein E;
Brain injuries;
Electroencephalogram;
Gene polymorphism
- From:
Chinese Journal of Trauma
2008;24(8):619-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the relationship between polymorphism of apolipoprotein E gene (APOE) and electroencephlogram in patients with mild/moderate traumatic brain injury. Methods (1) Venous blood for 2 ml was collected from 81 patients with mild/moderate traumatic brain injury on admission. APOE genotype was identified by PCR restriction fragment length polymorphism ( PCRRFLP). (2) All the patients were monitored by electroencephalogram for 2-3 times within a week after injury. X2 test and logistic regression analysis via SAS version 8.2 were performed to analyze the results of genotype and electroencephalogram and clinical data. Results The distributions of genetypes and alleles among 81 patients matched with Haldy-Weinberg Law. The findings of electroencephalogram were significantly different between patients with and without APOEε4 (P<0.05). Ten (63%) out of 16 patients with APOEε4 showed an aggravated electroencephalogram,while only 16 (25%) out of 65 patients without APOEε4 showed the same results of electroencephalogram. Logistic regression analyses showed that APOEε4 was a risk factor for electroencephalogram aggravation after traumatic brain injury. Conclusion APOEε4 is a risk factor for electroencephalogram aggravation during acute stage after mild/moderate traumatic brain injury.
