Effects of adiponectin on atherosclerotic plaque evaluated by intravascular ultrasound in rabbits
- VernacularTitle:血管内超声评价脂联素对动脉粥样硬化斑块的影响
- Author:
Changjiang LI
;
Mei ZHANG
;
Yun ZHANG
;
Huiwen SUN
;
Liang CHEN
;
Yuanyuan RONG
;
Rong WANG
- Publication Type:Journal Article
- Keywords:
Endosonography;
Carotid stenosis;
Atherosclerosis;
Adiponectin
- From:
Chinese Journal of Ultrasonography
2008;17(8):716-719
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of adiponectin on the development of atherosclerosis.Methods The in vivo role of adiponectin on the development of atherosclerosis in rabbits was investigated mainly using adiponectin-producing adenovirus(Ad-APN)and intravascular ultrasound(IVUS).On day 14 after Ad-APN local transfer to the intima of abdominal aortas,abdominal IVUS images were recorded and then rabbits were sacrificed.Abdominal aortas were collected and performed histochemical analysis.Results Ultrasonography revealed a significantly reduced atherosclerotic area,in abdominal aortas of rabbits infected through intima with Ad-APN,by 36.39% compared with the area in adenovirus expressing β galactosidase gene(Ad-βgal)treated rabbits(P＜0.01),and by 37.50% compared with that before treatment(P＜0.01).The lumen area stenosis was also reduced by 23.37%(P＜0.05)and 33.15%(P＜0.01),respectively.In rabbits with Ad-APN infection,the atherosclerotic plaque area as seen on Oil Red O staining was reduced significantly,by 30.70%(P＜0.05)and the greatest thickness of plaque was reduced,by 20.83%(P＜0.05)as compared with those in Ad-βgal-treated rabbits,respectively.Conclusions Intravascular ultrasound analysis is a valuable method in the in vivo study about the effects of adiponectin on the development of atherosclerosis.
