Hepatic Graft-Versus-Host Disease: Three Cases Proven By Laparoscopic Liver Biopsy.
- Author:
Hwang CHOI
1
;
Joon Yeol HAN
;
Jong Wook LEE
;
Jae Kwang KIM
;
Chun Choo KIM
;
Kyu Won CHUNG
;
Hee Sik SUN
;
Dong Jip KIM
Author Information
1. Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
GVHD;
Liver;
Laparoscopy
- MeSH:
Bile Ducts;
Biopsy*;
Bone Marrow Transplantation;
Cholestasis;
Disease Progression;
Early Diagnosis;
Graft vs Host Disease*;
Humans;
Korea;
Laparoscopy;
Liver Cirrhosis, Biliary;
Liver*;
Mortality;
Necrosis;
Siblings
- From:Korean Journal of Medicine
1998;55(3):420-426
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hepatic graft-versus-host disease (GVHD) occurs in nearly one-third of recipients of HLA-identical sibling bone marrow transplantation (BMT), and is a major cause of morbidity and mortality following BMT. Hepatic dysfunction after BMT may result from a number of causes such as pretransplant chemoradiation, drugs for GVHD prophylaxis, venoocclusive disease, various infections, GVHD, and infiltration of recurrent malignancy. The clinical distinction of these causes may be difficult and the treatment of each causes is quite different. Therefore the early diagnosis of GVHD is very important. Hepatic GVHD is recognized to immunologic disorder such as primary biliary cirrhosis, and is characterized by cholestasis due to extensive bile duct damage and mild hepatocellular necrosis. In Korea, the occurrence of GVHD is about 20-45%. We report three cases of severe hepatic GVHD after allogeneic BMT, which were proven by laparoscopic liver biopsy in 1996. There were differences in primary illness, associated condition and disease progression.
