Clinical significance of anti-ribosomal P0 protein antibodies
- VernacularTitle:系统性红斑狼疮患者抗核糖体P0蛋白抗体的临床意义
- Author:
Xi CHEN
;
Yi ZHENG
;
Shanshan CHEN
;
Xin DONG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Ribosomal RNP;
Anti-ribosomal P0 protein antibodies
- From:
Chinese Journal of Rheumatology
2008;12(8):565-567
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical value of anti-ribosomal P0 protein antibodies (anti-P0). Methods Line immuno-assay and immunoblotting methods were used to detect anti-P0 and rRNP antibodies of 49 SEE patients and 61 patients with other rheumatic diseases.The expressions of anti-P0 were compared with those of rRNP antibodies.Possible relations between anti-P0 and clinical features and other antibodies in SLE were explored.Results 36.7%and 6.1% of SEE patients showed positive anti-P0 and rRNP antibodies respectively.Anti-P0 was always negative in patients with other rheumatic diseases (P＜0.01).Among SLE pa tients,incidence of skin rash was 77.8%(35.5%) ff anti-P0 was found to be positive (negative) (P＜0.05). Besides,for patients with positive and negative anti-P0,the chance of positive anti-SmD1 was 61.1% and 19.4% respectively (P＜0.01).Sensitiviy of anti-P0 for SLE diagnosis was 36.73% with specificity and positive predictive value as high as 100%,and 66.30% as the negative predictive value.Conclusion Sera anti-P0 is highly specific for SLE and it is associated with the occurence of rash and the expression of anti-StuD 1 anti bodies in SEE.
