Expression and significance of HSG/Mfn2 and P21 WAF1 in non-small cell Lung cancer
- VernacularTitle:细胞增殖抑制基因、p21WAF1蛋白在非小细胞肺癌组织中的表达及其意义
- Author:
Huanran DING
;
Guangjian JIANG
;
Liren MA
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
Hyperplasia suppressor gene/Mitofusin2;
P21 WAF1 protein
- From:
Clinical Medicine of China
2008;24(10):961-963
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of hyperplasia suppressor gene(HSG)/mitofusin 2 (Mfn2)and P21 WAF1 in non-small cell lung cancer(NSCLC).Methods The expression of(HSG/Mfn2)and P21 WAF1 was detected in 92 cases of NSCLC samples by immunohistochemistry(SP).Results The absorptance value of the expression of HSG/Mfn2 in squamous cell carcinoma,adenocarcinoma,and non-cancer tissue were 15.06±2.73,12.21±2.96 and 10.36±3.60,respectively(P<0.05),and they were associated with tumor differentiation.The absorptanee valtue of the expression of P21 WAF1 in squamous cell carcinoma,adenocarcinoma,and non-cancer tissue were 3.16±0.98,3.44±0.22,0.06±0.32.The expression of P21 WAF1 in squamous cell carcinoma and adenocarcinoma Was higher than that in non-cancer tissue(P<0.05),and was closely associated with tumor differ-entiation and lymph node metastasis.Conclusion HSG/Mfn2,P21WAF1 is closely related to the pathogenesis and development of lung cancer.There is positive correlation between the HSG/Mfn2 and P2l WAF1 in lung cancer.
