Experimental study on effect of chlorogenic acid on oxidative stress of kidney in diabetic rats
- VernacularTitle:绿原酸对糖尿病大鼠肾脏氧化应激作用的实验研究
- Author:
Longtao LEI
;
Liangge SUN
;
Tianyi LI
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Chlorogenic acid;
Oxidative stress;
Rat
- From:
Clinical Medicine of China
2008;24(10):963-965
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Chlorogenic acid on oxidative and antioxidative system of kidney in diabetic rats.Methods 36 rats were randomly divided into three groups:normal group(N group),diabetes mellitus group(DM group)and diabetes group treated with chlorogenic acid(CA group).Ten weeks later,blood glu-cose,weight of body and kidney ,the activity of superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX)lipidperoxidation(MDA),urinary albumin excretory rate(UARE)in renal tissue were measured.Results The levels of blood glucose were not significantly different between DM group and CA group,but the weight of rats and kid-ney and the activity of SOD and GSH-PX in CA group were higher than DM group,and MDA and UAER of CA group were lower(P<0.05 for each).Conclusion Chlorogenic acid effective in improving the antioxidativity,inhibiting oxidative stress and decreasing urinary albumin.
