Intratracheal anti-tumor necrosis factor-α antibody effect on ultra-structure of lung after cardiopulmonary bypass
- VernacularTitle:抗肿瘤坏死因子抗体对体外循环肺组织超微结构的影响
- Author:
Yang YU
;
Qin LI
;
Hui HU
;
Xiao LIU
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
Anti-tumor necrosis factor-α antibody;
Lung injury;
Pulmonary protection;
Apoptosis
- From:
Clinical Medicine of China
2008;24(10):977-979
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of intratracheal anti-tumor necrosis factor-α antibody(TNF-αAb)on ultra-structure of lung after cardiopulmonary bypass(CPB).Method 28 healthy rabbits were selected and randomly evenly divided into four groups:I group only received open chest operation;Ⅱ-Ⅳ groups underwent CPB.In the IV group,rabbit TNF-α Ab (2400 ps/kg)Was dropped into the intracheal tube before operation and just after releasing the aortic clamp.Saline was given to the Ⅲ group by the same way.Water volume,TNF-α mRNA,TNF-α protein,apoptosis and pathomorphological changes were measured in the lung tissues.Results TNF-α Ab can re-duce releasing of TNF-α.It could also reduce the occurrence of apeptosis and attenuate pathomorphological changes in the lung tissue.Conclusion Intratracheal TNF-α Ab markedly lessenes the injury of nltrastructure of lung after CPB.
