Expression and significance of Th1/Th2 cytokines in ankylosing spondylitis
- VernacularTitle:Th1/Th2细胞因子在强直性脊柱炎中的表达及其意义
- Author:
Junxiang WANG
;
Ping WEI
;
Jinghong MENG
;
Xiuchan LIU
;
Yanjie LIU
;
Guang GU
;
Haiying CHEN
;
Jianli XIE
- Publication Type:Journal Article
- Keywords:
Ankylosing spondylitis;
Cytokines;
Tumor necrosis factor-α;
Interleukin
- From:
Clinical Medicine of China
2008;24(10):989-990
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and significance of Th1/Th2 cytokines in ankylosing spondyhtis (AS).Metbotis Serum and synovial fluid levels of TNF-α,IL.17.IL-10 and IL-4 were detected by en-zyme linked immunosorbent assay(ELISA)in AS cases.Results The serun levels of TNF-α,IL-17 and IL-10 were significantly higher,while the serum level of IL-4 Was significantly lower in AS group than in normal group.The levels of TNF-α.IL-17 and IL-4 in synovial fluid were significantly higher than in serum.Conclusion Disequilibrium exists in Th1/Th2 cytokine network of AS.and there is a strong predominance of Th1.
