Clinical significance of virus infection and serum interleukin-2 levels in recurrent childhood idiopathic thrombocytopenic purpura
- VernacularTitle:儿童复发性特发性血小板减少性紫癜病毒感染与白细胞介素-2水平的临床意义
- Author:
Jinkai WEI
;
Huizhe LIU
;
Xin WANG
;
Yuehong XU
;
Hao JIA
- Publication Type:Journal Article
- Keywords:
Idiopathic thrombccytopenic purpura;
Childhood;
Virus infection;
Intedeukin-2
- From:
Clinical Medicine of China
2008;24(10):1005-1006
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance of vires infection and serum interleukin-2 (IL-2)Ievels in recurrent childhood idiopathic thrombocytopenic purpura(ITP).Methods The cytomegalovirus(CMV),epstein-Barrvirus(EBV)-adenovirus(ADV),herpesvirus(HSV)antibodies ISM and IL-2 levels were determined in the serum of 4 childhood with recurrent childhood ITP as well as in 40 normal controls with ELISA and RIA.Re-sults The CMV-lgM positive cases were 18,EBV-IgM were 14-ADV-IgM were 5,HSV-lgM were 3.In the controls,those were 3,2,1,and 0 respectively(P<0.05 or P<0.01).The serum IL-2(0.35±0.12)μg/L levels were sig-nificantly lower than those in the controls[(0.61±0.17)μ/L,P<0.05].Conclusion DNA virus antibodies and IL-2 levels can reflect virus infection and immune condition of diseases in recurrent childhood ITP.It is impor-rant to comprehend the mechanism of recurrent childhood ITP for guiding clinical treatment.
