Relationship between expressions of COX-2.VEGF-C in breast cancer and lymphatic metastasis
- VernacularTitle:乳腺癌组织中COX-2、VEGF-C表达与淋巴转移的相关性研究
- Author:
Zhijie XU
;
Chengquan WANG
;
Yafeng XIE
;
Wenbiao XIE
- Publication Type:Journal Article
- Keywords:
breast cancer;
lymphatic metastasis;
cyclooxyenase-2 (COX-2);
vascular endothelial growth factor-C (VEGF-C)
- From:
International Journal of Surgery
2008;35(8):521-524
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions of COX-2 and VEGF-C in breast cancer and to explore the relationship between their expressions and lymphatic metastasis. Methods Immunohistochemical stai- ning (SABC) was used to detect the expressions of COX-2 and VEGF-C proteins in 60 cases of breast canc- er. Results The positive rate of COX-2 and VEGF-C in breast cancer were 66.7% and 60. 0%, and the expression of COX-2 was positively correlated with VEGF-C (r =0.429, P<0.05). COX-2 and VEGF-C expressions were positively correlated with lymphatic metastasis (P<0.05). The lymphatic metastasis rate in the positive group of COX-2 and VEGF-C were higher than that in the negative group of COX-2 and VEGF-C. Conclusion Over expression of COX-2 and VEGF-C were observed in breast cancer, and closely related to lymphatic metastasis. COX-2 has positive correlation with VEGF-C and was correlated with lym- phatic metastasis of breast cancer. COX-2 may promote the over expression of VEGF-C in tumor cells and cause lymphatic metastasis.
