Prognostic Value of Volume-Based 18F-Fluorodeoxyglucose PET/CT Parameters in Patients with Clinically Node-Negative Oral Tongue Squamous Cell Carcinoma.
10.3348/kjr.2012.13.6.752
- Author:
Su Jin LEE
1
;
Joon Young CHOI
;
Hwan Joo LEE
;
Chung Hwan BAEK
;
Young Ik SON
;
Seung Hyup HYUN
;
Seung Hwan MOON
;
Byung Tae KIM
Author Information
1. Department of Nuclear Medicine, Ajou University School of Medicine, Suwon 443-721, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
18F-FDG PET/CT;
Oral tongue squamous cell carcinoma;
SUV;
Metabolic tumor volume;
Total lesion glycolysis;
Prognosis prediction
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell/diagnosis/mortality/pathology/*radionuclide imaging;
Female;
Fluorodeoxyglucose F18/*diagnostic use;
Humans;
Lymphatic Metastasis;
Magnetic Resonance Imaging;
Male;
Middle Aged;
*Positron-Emission Tomography and Computed Tomography;
Prognosis;
Radiopharmaceuticals/*diagnostic use;
Survival Rate;
Tomography, X-Ray Computed;
Tongue Neoplasms/diagnosis/mortality/pathology/*radionuclide imaging;
Young Adult
- From:Korean Journal of Radiology
2012;13(6):752-759
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the prognostic value of volume-based metabolic parameters measured with 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) in patients with clinically node-negative (cN0) oral tongue squamous cell carcinoma (OTSCC) as compared with other prognostic factors. MATERIALS AND METHODS: In this study, we included a total of 57 patients who had been diagnosed with cN0 tongue cancer by radiologic, 18F-FDG PET/CT, and physical examinations. The maximum standardized uptake value (SUVmax), average SUV (SUVavg), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for primary tumors were measured with 18F-FDG PET. The prognostic significances of these parameters and other clinical variables were assessed by Cox proportional hazards regression analysis. RESULTS: In the univariate analysis, pathological node (pN) stage, American Joint Committee on Cancer (AJCC) stage, SUVmax, SUVavg, MTV, and TLG were significant predictors for survival. On a multivariate analysis, pN stage (hazard ratio = 10.555, p = 0.049), AJCC stage (hazard ratio = 13.220, p = 0.045), and MTV (hazard ratio = 2.698, p = 0.033) were significant prognostic factors in cN0 OTSCC patients. The patients with MTV > or = 7.78 cm3 showed a worse prognosis than those with MTV < 7.78 cm3 (p = 0.037). CONCLUSION: The MTV of primary tumor as a volumetric parameter of 18F-FDG PET, in addition to pN stage and AJCC stage, is an independent prognostic factor for survival in cN0 OTSCC.
