Farnesoid X receptor dependent bile acid signaling regulates bile acids metabolism
- VernacularTitle:核受体FXR依赖胆汁酸信号对胆汁酸代谢的调节
- Author:
Xiushan DONG
;
Haoliang ZHAO
- Publication Type:Journal Article
- Keywords:
famesoid X receptor;
bile acid;
metabolism
- From:
International Journal of Surgery
2008;35(8):565-568
- CountryChina
- Language:Chinese
-
Abstract:
The Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and has emerged as a key player in the control of multiple metabolic pathways. Bile acids are the major endogenous ligands for FXR, and by activating FXR have a variety of target genes, many of which are geared toward pre- venting synthesis and uptake and promoting excretion of bile acids. Here we summarized the latest results from studies on FXR target genes and functions in bile acids metabolism in this article.
