Effect of JNK pathway, endoplasmic reticulum stress and oxidative stress on pancreatic islet β cell function
- VernacularTitle:c-Jun氨基端激酶通路、内质网应激、氧化应激与胰岛β细胞功能
- Author:
Zhiqiang HOU
;
Hongliang LI
;
Guangwei LI
- Publication Type:Journal Article
- Keywords:
JNK pathway;
Endoplasmic reticulum stress;
Oxidative stress;
Pancreatic islet β cell function
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(3):348-350
- CountryChina
- Language:Chinese
-
Abstract:
Though the mechanisms involved in the induction of pancreatic islet β cell dysfunction and apoptosis under diabetes conditions are still not clear, previous studies have shown that triggered or aggravated endoplasmic reticulum stress and oxidative stress play essential roles in impairment of β cell functions, especially the JNK pathway which can be activated by both of them.
