The impact of chronic stress on the behaviors and the expression of brain-derived neurotrophic factor in the prefrontal cortex of rats
- VernacularTitle:慢性应激对大鼠前额叶脑源性神经营养因子表达的影响
- Author:
Ru HE
;
Yun XIAO
;
Xiaohong FENG
- Publication Type:Journal Article
- Keywords:
Stress;
Prefrontal cortex;
Brain-derived neurotrophic factor(BDNF);
Neural protection
- From:Chinese Journal of Behavioral Medicine and Brain Science
2008;17(6):523-524
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relation between chronic stressful, the neural changes in prefrontal cortex and depression. Methods Adapt chronic unpredictable stress with separate model to make depression model rats. After 22 days all the rats were killed and use immunohistochemistry method and computer image analysis to detect BDNF. To analysis the date with SPSS11.5 software. Results After 21 days stress, body weight ( t =2.915, P < 0.05), ambulation ( t = 6. 245, P < 0. 01 ), rearing( t = 2.693, P < 0. 05 ) and grooming ( t = 2. 685, P<0.05) decreased and stopping time in center( t=2. 388, P<0. 05) ,defecation( t =3. 846, P<0. 01 ) increased in experimental group. BDNF expressed obviously in control group and the prefrontal cortex expressed highly than that of the experimental group. BDNF expressions of experimental group were lower than that in control group ( P< 0.01 ) especially in right prefrontal cortex. Conclusion There was no difference of BDNF distribution in prefrontal cortex between both groups ,but after 21 days stress ,the BDNF levels of experimental rats obviously descent,especially in right prefrontal cortex.
