Guidance on select of anti-virus treatment method of HBV DNA and HBeAg quantification with hepatitis B patients
- VernacularTitle:HBV DNA及HBeAg定量在乙型肝炎患者抗病毒治疗方案选择中的指导作用
- Author:
Jing MA
;
Juan WANG
;
Jingyu SUI
;
Donge WANG
;
Ying GUO
;
Zhicong LIANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B,Chronic;
Hepatitis B e antigens;
Interferons;
Quantification;
Adefovir dipivoxil
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(18):17-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the best treatment for hepatitis B by observing the efficacy d interferon and adefovir dipivoxil (ADV) according to different combination of various quantification of HBV DNA and HBeAg. Methods One hundred and sixty-five hepatitis B antigen-positive patients were divided into four groups (A, B, C, D group) according to different quantification of HBV DNA and HBeAg. Each group was randomly divided into two sub-groups with interferon and the others with ADV. Items were observed in 48 weeks and statistic analysis was made to observe if there was significant difference between two methods in each group. Results There was no difference in the rate of HBV DNA inhibitory activity, HBV DNA clearance and ALT normalization as well as HBV DNA decreasing (level≥2lg copy/ml). But there was significant difference in the rate of HBeAg clearance, HBeAg seroconversion and HBeAg decreasing level ≥500.00 COL/ml (P<0.05). The efficacy decreased following the increasing of HBV DNA and HBeAg quantification, especially in ADV groups. The efficacy of interferon was better in seroconversion rate. Conclusion Quantification of HBV DNA and HBeAg can be the guidance to select different anti-virus methods.
