Effect of the genetic variants of heme oxygenase-1 gene on blood pressure level in hypertensive pailents
- VernacularTitle:血红素加氧酶1基因多态性与血压水平的关系分析
- Author:
Yun LI
;
Xiaoli LIU
;
Laiyuan WANG
;
Jie CAO
;
Jianxin LI
;
Xiangfeng LU
;
Jianfeng HUANG
;
Dongfeng GU
- Publication Type:Journal Article
- Keywords:
Heme oxygenase;
Polymorphism;
Haplotype;
Blood pressure;
Tag SNP
- From:
Clinical Medicine of China
2008;24(10):966-969
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the relationship between the polymorphisms of heme oxygenase-1 gene and blood pressure level.Methods With the whole-gene based tagging SNP approach,3 tag SNPs of heme oxygenase-1 gene were selected for study.These tag SNPs were genotyped in 503 essential hypertension cases Blood pressure lev-els among different genotypes of each SNP were compared with ANOVA.The haplo.stats program wa8 employed to test haplotype frequency with blood pressure level.Results Subjects with rs2071749 A allele had the lower blood pressure levels than subjects with GG genotypes(SBP:159.5 mm Hg vs.168.5 mm Hg and DBP:97.6 mm Hg vs.101.3 mm Hg respectively.P<0.05).In the haplotype analyses.Haplotype T-T-A which carried the rs2071749 A allele was found significantly associated with SBP and DBP after adjustment for age,gender,body mass index.8n10k.illg and drinking·Conclusion The genetic variants of heine oxygenase.1 gene misht be associated with blood pres-sure levels.
