Effect of nerve growth factor on adrenergic nerve in rals after myocardial infarction
- VernacularTitle:神经生长因子对心肌梗死后大鼠肾上腺素能神经的影响
- Author:
Xiuqin NI
;
Xing LI
;
Jia FENG
;
Linghui HAO
;
Changwei JI
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Nerve growth factor;
Adrenergic nerve
- From:
Clinical Medicine of China
2008;24(10):991-993
- CountryChina
- Language:Chinese
-
Abstract:
Objective To confirmthe protective effect of nerve growth factor (NGF)on cadiac adrenergie nerve in rats after acute myocardial infarction(AMI)and its mechanism.Methods 120 Wister rats were divided in-to sham-operated group.AMI group and NGF group.The samples were taken after6 h, d,4 d-7 d and 14 d sepa-lately.Immunohistochemistry method WaS used to show the distribution of adrenergic nerve fibers.The density of them were calculated by Medical Pathobgical Image Analysis Processing System.Results ①The densities of adrenergic nerve fibers in AMI group were obviously lower than that of sham-operated group greatly in 6 h and 2 d.4 d-7 d and14 d later.②The densities of adrenergic innervation in NGF group were obviously higher than that of AMI group 7 dand 14 d later.Conclusion NGF has protection effect 011 cardLac adrenergic nerve after AMI in the rat.
