Effects of retroperfusion on the levels of serum soluble inetr cellular adhesion molecule-1,soluble P-selectin and cardiac troponin Ⅰin patients of cardiac operation under direct vision
- VernacularTitle:逆行灌注对心脏瓣膜置换术患者血清可溶性细胞间黏附分子-1、可溶性P-选择素和心肌肌钙蛋白Ⅰ的影响
- Author:
Zhonglu CHANG
;
Jintao HE
;
Yanlu ZHANG
;
Zhongtang CHEN
;
Yanli QIAO
;
Liang SUN
;
Qingwei CHEN
- Publication Type:Journal Article
- Keywords:
Myocardial reperfusion;
Cardiac surgical procedures;
Cell adhesion molecules;
TroponinⅠ
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(23):3-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of retrograde cardioplegia on serum soluble inter cellular adhesion molecule (sICAM)-1,soluble P-selectin (sPs) and cardiac troponin Ⅰ(cTnI) in the process of heart valve replacement operation.Methods Fifty-six cases undergoing heart valve replacement with cardiopulmonary bypass (CPB) were divided into antegrade cardioplegia (AC) group and retrograde cardioplegia (RC) group.Serum levels of sICAM-1,sPs and cTnI were measured using enzyme-linked immunosorbent assayd (ELISA) at six times.Results After the CPB,the levels of sICAM-1,sPs and cTnI ascended quickly,at the time of 8-hour after operation achieved the peak value.The peak value of RC group were lower than those of AC group[sICAM-1 (817.9±133.2)μg/L vs(901.1±132.0)μg/L,sPs(83.46±16.24)μg/L vs(107.82±19.68) μg/L,cTnI(10.50±2.03) μg/L vs (14.45±2.26)μg/L],and the dedined degree of RC group were faster than those of AC group.Conclusion Retroperfusion has a better myocardial protection to the patients suffering heart valve replacement operation through active suppressed expression of sICAM-1,sPs and cTnI palliated inflammatory reaction.
