Clinical effects of cytokine induced killer cells treatment combined with radiofrequency ablation on liver metastases
- VernacularTitle:局部消融术联合细胞因子诱导的杀伤细胞治疗肝转移瘤临床效果观察
- Author:
Cheng WANG
;
Rongcheng LUO
;
Peng SHEN
;
Fei CUI
- Publication Type:Journal Article
- Keywords:
Liver metastases;
Radiofrequency ablation;
Cytokine induced killer cells;
Efficacy
- From:
Clinical Medicine of China
2008;24(9):935-937
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of cytokine induced killer (CIK) cells combined with radiofrequency ablmion (RFA) in treatment of liver metastases.Methods 23 patients were treated with CIK plus RFA, while 27 patients with RFA.Tumot markers and CD3+、CD4+、CD8+、CD4+/CD8+ were tested before and after treatment.Recurrence rate and Kamofsky score were also evaluated.Results The local recurrence rate in the study group was lower (13.04% vs.40.74%)(P<0.05),CD3+、CD4+、and CD4+/CD8+ were increased (P<0.01). The percentage of patients with decreased tumor markers and increased Kamofsky is higher (P<0.05);Conclusion The therapy of CIK combined with RFA has better efficacy on liver metastases,can enhance the cellular immune functions and improve the quality of life significantly.
