Prolactin protein and Zinc transporter 1 mRNA expressions in weanling rats following heat stress and febrile convulsions
- VernacularTitle:热惊厥幼龄大鼠脑内Prolactin蛋白及Zinc transporter 1 mRNA表达
- Author:
Hong NI
;
Quanxiang SHUI
- Publication Type:Journal Article
- Keywords:
Febrile convulsion;
Heat stress;
Prolactin;
Zinc transporter 1(ZnT1)
- From:
Chinese Journal of Emergency Medicine
2008;17(8):807-811
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of prolactin protein and ZnT1 mRNA in rat brain in the wake of heat stress and febrile convulsion(FC).Method Thirty-six weanling Spragne-Dawley rats were randomly divided into control group(n=8) and other 28 rats were used to induce heat stroke by warm water but three of them failed to produc expected heat stress.Consequently,there were 35 rats eligible to be models of heat stroke,and of them,10 rats showed heat stress(HS group,n=10) and 15 rats had 5-grade febrile convulsion (FC group,n = 15).The inmmunohistocbemistry and in situ hybridization method were used in this study.The IR) neurons were found in the rats of control group.The deep immune staining was found in the PIR,Era and RS regions of cerebral cortex and light immune staining was found in the PRH,PAR and FR regions of cerebral cortex in HS group.In addition,the PRL-IR positive neurons were found around the midline strip of thalamus without characteristic subnucleus-specific distribution.However,abundant induction of PRL-IR positive neurons with diffuse distribution were found in cerebral cortex,hippoeampus,amygdala,thalamus and hypotha]amns of rats in FC and FC rats showed more PRD-IR positive neurons in cerebral cortex than those in rats of control group (P
