The value of early short-time veno-venous hemodialysis in reducing IL-6 in patients with severe acute pancreatitis
- VernacularTitle:血滤清除白细胞介素6治疗重症急性胰腺炎
- Author:
Biao ZHANG
;
Bojian JIANG
;
Yiming ZHU
;
Dazheng WANG
- Publication Type:Journal Article
- Keywords:
Pancreas;
Inflananation;
Hemedialysis;
lntedeukin-6(IL-6)
- From:
Chinese Journal of Emergency Medicine
2008;17(8):855-858
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic effect and mechanism of IL-6 reduced by the early shortlime veno-venous hemodialysis (BVVH) for the treatmnent of severe acute pancreatitis (SAP).Method One hundred and seventy-eight cases with SAP,in depagtment of general surgery,the Third People Hospital,Shanghai Jiao Tong University School of Medicine,were divided inlo hemodialysis group (HF,85 cases) and non-hemodialysis group (NHF,93 cases).The local and systemic manifestations,APACHE Ⅱ scores,average hospitalizing stay,mean cost of therapy,morbidity of MODS and the mortality of patients were compared between two groups.And the concentration of serum inflammatory factor IL-6 was assayed at different observation intervals.All data were managed by SPSS software and analyzed by using SNK-q test or X2 test.Results The duration for abdominal pain and distension in patiergs of HF group was (18.8+=4.2) h vs.(89.7±28.1) h in those of NHF group,P<0.05.The APACHE Ⅱ scores at the 10th day were (5.5±3.6) vs.(13.8±3.8) (P<0.05).The average hospitalizing stay and the mean costs of medical care were (28.2+ 12.4) d vs.(42.4+11.2) d and (43800±28000) vs.(74600±22000) RMB(P<0.05) respectively.The concontrafion of serum inflammatory factor IL-6 in HF group decreased significantly(P<0.05) in comparison with those in NHF group.And the morbidity such as MODS and the mortality in HF group were significantly less than those in NHF group(P<0.05).Conclusions By BWH,the excessive release of serum inflammatory factor IL-6 could he removed at early stage of SAP.So,it could result in an improving on the severity of the disease and raise the therapeutic efficacy.
