Expression of HIF-1α and survivin in gastric cancer
- VernacularTitle:胃癌中缺氧诱导因子-1α与Survivin表达的相互关系及临床病理意义
- Author:
Wei SUN
;
Yu ZHAO
;
Lin GUO
;
Qiang WANG
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
HIF-1α;
Survivin;
Immunohistochemistry
- From:
Clinical Medicine of China
2008;24(9):885-888
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of HIF-1α and survivin in gastric cancer,and to study their role in tumor angiogenesis,invasion and metastasis.Methods Immunohistochemieal technique was used to detect the expression of HIF-1α and survivin in 54 cases of gastric cancer.Results The expression rate of HIF-lα in gastric cancer (74.1%) was higher than that in normal gastric tissue (O),The expression of HIF-1α in gastric cancer was associated with TNM staging,invasive depth and lymph-node metastasis (P<0.05),The expression of survivin in gastric cancers was high (72.2%),and increased with invasive depth (P<0.01),clinical stages (P<0.01) and lymphatic metastasis (P<0.05).There was a positive correlation between expression of HIF-1α and Survivin (r:0.31,P<0.05).Conclusion HIF-1α and Survivin could be factors in the judgement of the degree of malignancy of gastric cancer and prediction of its prognosis.
