Influence of the of ultramicro-dosage heparin combining with low-molecule dextran on D-dimer in serum of infant patients with severe pneumonia
- VernacularTitle:超微剂量肝素并低分子右旋糖酐对婴幼儿重症肺炎血清D-二聚体的影响
- Author:
Lianying JIANG
;
Yuan TANG
;
Chuanyong LIU
;
Hua KE
- Publication Type:Journal Article
- Keywords:
Pneumonia;
Heparin
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(24):29-31
- CountryChina
- Language:Chinese
-
Abstract:
Objeetive To observe the curative effect of ultramicro-dosage heparin (UMDH) combining with low-molecule dextran (LMD) on the D-dimer positive infant with severe pneumonia.Methods sixty-eight infant patienls.whose D-dimer in serum were positive,were randomly divided into two gmaps cutaneous injection for 4 times.Arier the D-dimer in serum became negative,the drug was stpped.In the heparin combining with LMD (HCLMD) group,the UMDH (same dosage as above) was used combining with the LMD.The dosage for LMD was 5 ml/kg once with general-speed intravenous drip and 1-2 times a day,which should be continued until the D-dimer in serum became negative.Results After 2-day's trestment,there was no obvious differences in the negative transfer rate of D-dimer between two groups(P＞0.05).However,after 3-4 day's treatment,the negative transfer rate in HCLMD group was absloutely higher than that in heparin group,there were obvious differences in two groups(P＜0.05).As for the death rate of illness,the death rate in HCLMD group was lower than that in hepari.group,being respectively 5.88% and 17.65%.Conclusion The use of UMDH combining with small-dosage LMD dextran can quickly improve the high condemation situation of blood and reverse the condition of infant patients with severe pneumonia.
