Influence of anisodamine chronic administration on the vascular function and morphology spontaneously hypertensive rats
- VernacularTitle:山莨菪碱慢性给药对自发性高血压大鼠主动脉功能及形态的影响
- Author:
Lie WANG
;
Jing GUO
;
Hong CHEN
;
Chengjin LI
- Publication Type:Journal Article
- Keywords:
anisodamine;
aortic rings;
vascular function;
vascular morphology
- From:
International Journal of Surgery
2008;35(8):510-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of Anisodamine chronic administration on the vascular function and morphology of SHR. Methods The SHR were injected by chronic abdominal Anisodamine; Then the SHR were sacrificed after ten weeks. The abdominal aorta were obtained after perfusion and the changes of aorta morphology were observed under a microscope. The influence of Anisedamine on the vasculovr funtion was investigated by the rat's aorta rings perfusion. Results In the physiological state, given SHR long-term Anisodamine, the vascular endothelial and smooth muscle relaxation will significantly improve; Anisodamine chronic adminstration can inhibit the formation of aortic aneurysm and change a benign vascular structure. Conclusion Anisodamine chronic adminstration will improve the vascular endothelial and smooth muscle relaxation, and change a benign vascular structure, Anisodamine has a protective effect on endothelial and smooth muscle.
