Corticotropin-releasing factor and its receptor in gastrointestinal disease
- VernacularTitle:CRF及其受体在胃肠疾病中的研究进展
- Author:
Baoqing MA
;
Guang BAI
- Publication Type:Journal Article
- Keywords:
corticotropin-releasing factor;
corticotropin-releasing factor receptor;
gastrointestinal disease
- From:
International Journal of Surgery
2008;35(8):546-549
- CountryChina
- Language:Chinese
-
Abstract:
Corticotropin-releasing factor (CRF)is a neuroendoerine peptide that stimulates the synthesis and release of adrenecortieotropic hormone from the pituitary. CRF widely distributed in the body has been implicated in the regulation of endocrine, neural, behavioral responses and has relevance in the the physio- logical effects and pathophysiology of gut. The delayed gastric emptying, inhibited small intestinal transit and stimulated colonic transit are the most common responses evoked by CRF. CRF delay gastric emptying by ac- tivating CRF2 receptor while the stimulation of colonic motility is mediated by the activation of CRF1 recep- tor. Development of antagonists of CRF receptor may treat a new therapeutic strategy for treatment of stress- related gastrointestinal disease.
