Molecular adsorbent recycling system for acute liver failure patients
- VernacularTitle:应用分子吸附循环系统治疗急性肝功能衰竭的经验
- Author:
Ke LI
;
Qifa YE
;
Yingzi MING
;
Jinzhong YUAN
;
Wanping CHEN
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Liver failure,acute;
Liver,artificial
- From:
Chinese Journal of General Surgery
2008;23(8):592-595
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study molecular adsorbent recycling system (MARS) in the treatment of patients with acute liver failure waiting for liver transplantation. Methods The effects of MARS artificial liver treatments in 16 cases were reviewed. Results There was a remarkable improvement in clinical symptoms and physical signs after MARS treatment, including significant decrease in prothrombin time, total bile acid, level of alanine aminotransferase, aspartate aminotransferase, creatinine, and blood ammonia (P＜0.05＝;There was no statistical change in NO,TNF-α and IL-10(P＞0.05).Sequential organ failure assessment(SOFA)score decreased from 9.91±1.09 to 6.64±1.76 and Glascow coma score increased from 7.29±2.06 to 13.26±2.14.Fourteen patients were tided over to liver transplantation among them 13 patients survived and were successfully discharged from the hospital. The survival rate was 89.5%.Conclusion MARS is a safe and effective assistant device in bridging acute liver failure patients to liver transplantation.
