Taurine stimulates osteoblast differentiation via ERK1/2 signal pathway
- VernacularTitle:牛磺酸通过ERK1/2信号途径促进成骨细胞分化
- Author:
Ying LU
;
Lingqing YUAN
;
Hui XIE
;
Xianghang LUO
;
Xianping WU
;
Houde ZHOU
;
Eryuan LIAO
- Publication Type:Journal Article
- Keywords:
Taurine;
Alkaline phosphatase;
Osteocalcin;
Osteoblast;
Mitogen-activated protein kinase
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(4):387-388
- CountryChina
- Language:Chinese
-
Abstract:
This in vitro study demonstrated that taurine supplemented culture medium enhanced alkaline phosphatase (ALP) activity, osteocalcin secretion and mineralized matrix formation. Taurine induced activation of ERKI/2 and osteoblast differentiation, which was blocked by pretreatment of osteoblasts with ERKI/2 inhibitor (PD98059), suggesting taurine stimulated osteoblast differentiation via ERKI/2.