Investigation on hemorheologic changes in patients with chronic hepatitis B and its correlation with HBV genotype
- VernacularTitle:慢性乙型病毒性肝炎患者血液流变学特点及其与HBV基因特征的相关性分析
- Author:
Ximei GAO
;
Yajie LIN
;
Jing WANG
;
Xiaoyun YANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Hemorheologic changes;
Genotype;
Correlation
- From:
Chinese Journal of Practical Nursing
2008;24(24):12-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss hemorheologic changes and hepatic function in patients with chronic hepatitis B(CHB)and its correlation with HBV genotype.Methods Relative index of hemorheologic changes,ALT,HBV-DNA and HBV genotype were examined in 96 CHB patients and 24 healthy control people.The results underwent correlation analysis.Results Low-shear blood viscosity and RBC aggregation index were significantly higher in CHB patients than those in the healthy control people(P＜0.05).Low-shear blood viscosity and RBC aggregation index were significantly higher in CHB patients with abnormal ALT than those CHB patients with normal ALT and the healthy control people(P＜0.05).No statistical difference was seen when CHB patients with normal ALT were compared with the healthy control people and patients with positive HBV-DNA were compared with patients with nesative HBV-DNA(P＞0.05).No statistical difference was seen in hemorheologic changes in CHB patients with different genotype(P＞0.05).Conclusions Microcirculation disorder of CHB patients is correlated with damage degree of hepatic function.Hemorheologic changes are not correlated with HBV-DNA and HBV genotype,so it can be a relatively independent index for clinical evaluation of disease.
