Proliferative responses of peripheral blood mononuclear cell to various HBV antigen in the patients with hepatitis B
- VernacularTitle:乙型肝炎患者外周血单个核细胞对HBV不同区抗原的增殖反应
- Author:
Peng YAO
;
Nailing CHEN
;
Xiaohong ZHANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B Cellular immune Peripheral blood mononuclear cell
- From:
Chinese Journal of Infectious Diseases
1999;17(3):181-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of cell mediated immunity in HBV infection.Methods tive responses of peripheral blood mononuclear cell(PBMC)to hepatitis B virus antigen HBcAg,HBehg and HBsAg were studied in 20 patients with acute hepatitis B and 23 patients with chronic hepatitis B as well as 20 heath normal donrors.Results Patients with acute hepatitis B showed stronger proliferative responses of PBMC to HBV antigen than patients with chronic hepatitis B as wdl as normal donors.The responses to HBcAg and HBeAg were stronger than that to HBsAg in both acute and chronic group.It was also found that cellular pro|ifertive response,which showed no correlation with ALT level,was significantly increased in the patients with HBV DNA+or/and HBeAg+.Conclusion The results indicate that cellular immune responses to HBV antigens exist in peripheral blood of patients with hepatitis B and potentially play an essential role not only in eliminating virus but also in the pathogenesis of hepatitis B.
