Influence of leptin signal transducting system on ovary function in the db/db mouse
- VernacularTitle:瘦素信号转导系统对卵巢功能的影响
- Author:
Yuehui ZHANG
;
Xiaoke WU
;
Junwei QU
;
Yong WANG
;
Lihui HOU
;
Haixue KUANG
- Publication Type:Journal Article
- Keywords:
Ovary;
Leptin;
Leptin receptor;
Signal transduction
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(4):428-429
- CountryChina
- Language:Chinese
-
Abstract:
Four genotypic mice were constructed, by ovary transplantation, with body leptin receptor (LR) + and ovary LR - in Group A, body LR + and ovary LR + in Group B, body LR - and ovary LR + in Group C, as well as body LR - and ovary LR - in Group D respectively. Mice in C and D groups showed significant differences in glucose and fat metabolism as well as ovarian function as compared with A and B groups. Leptin signal transducting system exists in the ovary. Ovarian failure was induced by hyperlipidemia and lowered gonadotropin levels, but not by defective leptin signal within ovaries in the db/db mice.
