Progress of histone deacetylase in hepatocellular carcinoma
- VernacularTitle:组蛋白去乙酰化酶在肝癌中的研究进展
- Author:
Zhe YANG
;
Shusen ZHENG
- Publication Type:Journal Article
- Keywords:
carcinoma;
hepatocellular;
histone;
deacetylase
- From:
International Journal of Surgery
2008;35(9):609-612
- CountryChina
- Language:Chinese
-
Abstract:
Histone acetylation and deacetylation is an important regulatory way of gene expression in eukaryotic cells. As a key regulatory enzyme, histone deacetylase is overexpressed in many malignant tumors, including hepa- tocellular carcinoma. In addition, it has been suggested to be a potential therapeutic target for solid tumors. In this study, we review the classification, mechanisms, as well as the expression and regulation of histone deactylases in hepatocelhlar carcinoma.
