Advances of delta-like ligand 4 and tumour angiogenesis
- VernacularTitle:Delta样配体4与肿瘤血管生成的研究进展
- Author:
Baohua LI
;
Zongfang LI
- Publication Type:Journal Article
- Keywords:
Delta-like ligand 4;
Notch;
tumour;
angiognnesis;
VEGF
- From:
International Journal of Surgery
2008;35(9):636-639
- CountryChina
- Language:Chinese
-
Abstract:
Delta-like ligand 4 (D114), one ligand of Notch receptors, was highly expressed in turnout vessels and was a negative regulator in tumour angiogenesis. Blocking D114/Notch signaling could promote tnmour angiogen-esis, whereas due to poor peffnsion of newly forming vessels, tumour growth was inhibited, which was effective even to the tumour patients unresponsive to blocking VEGF pathway. So, D114 is becoming a new promising target in anti-tumour therapies.
