Tumor-specific promoters and their application in cancer gene targeted therapy
- VernacularTitle:肿瘤特异性启动子及其在肿瘤基因靶向治疗中的应用
- Author:
Xiaopeng CHEN
;
Lianghe HU
;
Chaogang TONG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Transcription initiation site;
Genes;
Target therapy
- From:
Journal of International Oncology
2008;35(8):566-569
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-specific promoters can induce high-efficiency and specific expression of exogenous genes in tumor cells. At present, commonly used promoters include alpha-fetoprotein promoter, carcinoembryonic antigen promoter,prostate specific antigen promoter,human telomerase reverse transcriptase promoter and multidrug resistance gene promoter and etc. Dual promoters, enhancer, regulatory element and other physical or chem-ical factors could be used to reconstruct or modify promoters to increase the expression and location of exogenous genes in tumor cells. Tumor-specific promoters play an important role in cancer gene targeted therapy by cou-pling with suicide gene, anti- oncogene, antiseuse nucleic acid, apoptosis gene and RNA interference.
