The significance of p16 protein and Ki-67 antigen expression in gastric mucosa-associated lymphoid tissue lymphoma
- VernacularTitle:胃黏膜相关淋巴样组织淋巴瘤中p16蛋白和Ki-67抗原的表达及意义
- Author:
Yue YANG
;
Zhenjun WEI
;
Yun ZHAI
;
Bin LIU
;
Hao LIANG
- Publication Type:Journal Article
- Keywords:
Stomach;
Lymphoma,mucosa-associated lymphoid tissue;
Protein p16;
Ki-67 antigen
- From:
Chinese Journal of Internal Medicine
2008;47(9):743-745
- CountryChina
- Language:Chinese
-
Abstract:
To detect the expression of p16 protein and Ki-67 antigen in gastric mucosa-associated lymphoid tissue lymphoma(MALTL)and normal gastric mucosa and to investigate the clinical significance of their expression in the occurrence and development of gastric MALTL.Methods 47 samples of gastric MALTL diagnosed pathologically in the department of pathology of the PLA General Hospital from March 1993 to June 2005 were collected.By using immunohistochemial methods,the expression of p16 protein and Ki-67 antigen was detected in 20 samples of normal gastric tissue and the 47 samples of gastric MALTL.Results The positive rate of p16 protein Was 21.3%(10/47)and 90.0% in gastric MALTL and normal gastric tissue respectively.The positive rate of p16 protein in gastric MALTL was lower than that in normal gastric tissue(P<0.05).The expression of p16 was related to the degree of lymph node metastasis.The positive rate of Ki-67 labelling index(LI)in gnstric MALTL was hiigher than that in normal gastric tissue.A negative correlation was found between the expression of p16 protein and Ki-67 LI(P<0.05). Conclusions Detection p16 and Ki-67 may help to predict the possibility of lymph node metastasis and prognosis in gastric MALTL.
