The reconstitutional profiles of peripheral blood natural killer cell,γδT lymphocyte and CD4+T cell in human immunodeficiency virus infected patients during one-year antiretroviral therapy
- VernacularTitle:抗病毒治疗对HIV/AIDS患者自然杀伤细胞和γδT细胞的重建作用研究
- Author:
Jing XIE
;
Zhifeng QIU
;
Yang HAN
;
Lingyan ZUO
;
Yanling LI
;
Zhengyin LIU
;
Taisheng LI
- Publication Type:Journal Article
- Keywords:
Acquired immunodeficiency syndrome;
HIV;
Immunity,natural;
Highly active antiretroviral therapy
- From:
Chinese Journal of Internal Medicine
2008;47(9):750-753
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the different reconstitutional profiles for acquired(CD4+ T cell)and innate(NK cell,γδT lymphocyte)immunity after highly active antiretroviral therapy(HAART).Methods The CD4+ CD4+,CD3+ CD4- CD8-,CD3- CD16/CD56+,CD4+ CD45 RA+ CD62 L+ and CD4+ CD45 RA- subsets were measured by flow cytometry.The dynamic changes of these subsets after HAART initiation were assessed in 59 patients who were followed for 12 months in resular 3-month visits.Results At baseline the cell counts of CD4+ T cells including its na(I)ve and memory subsets,NK cell and γδT cells in HIV/AIDS patients were all significantly lower than those of healthy individuals.There was a decrease of 2.33 lg copies/ml in HIV-1 RNA from baseline noted 1 month after initiation of treatment which was sustained through 12 months.CD4+ T cell count showed a bi-phase increase during treatment.The first rapid increase was mainly memory CD4+T cells and this followed by the second slow but steady increase of na(I)ve CD4+ T cells.Increases in NK cell and γδT cell were noted at 3 months of HAART and this restoration were different quantitatively when compared with the oge in CD4+ T cells.Conclusion HAART could induce a different quantitative restorational patterns in peripheral CD4+ T cells,NK cells and γδT cells.
