Effect of Liangruntongluo Recipe and its Modified Formula on Gastrointestinal MOT、 CCK、SS of Rats with Diabetes
- VernacularTitle:凉润通络方及其拆方对糖尿病大鼠胃肠MOT、CCK、SS的影响
- Author:
Diangui LI
;
Shiling RONG
;
Fengli WANG
;
Yongjian ZHANG
- Publication Type:Journal Article
- Keywords:
Liangruntongluo Recipe;
Diabetic gastrointestinal dysfunction;
Motilin (MOT): Cholecystokinin(CCK);
Somatostatin (SS)
- From:
International Journal of Traditional Chinese Medicine
2008;30(5):328-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of Liangruntongluo Recipe (Chinese medicines with functions of cooling, nourishing and dredging collaterals) and its modified formula in improving gastrointestinal function of diabete smellitus (DM) rats. Methods Male Wistar rats were used. Streptozotocin (STZ) was injected to rats to produce diabetic rat models. No Hypoglycemic drugs were administered to these rats to reduce blood glucose. After 18 weeks, warm water, Liangruntongino Recipe, Chinese medicines with function of nourishing, Chinese medicines with functions of cooling, and Cisapride were administered to the model rats. Detect the contents of plasma motilin (MOT), cholecystokinin (CCK), and somatostatin (SS) after 6 weeks. Results By affecting the secretion of gut hormone and having wide range of target, Liangrantongluo Recipe could regulate the disorder of gut hormone. The function of Liangruntongluo Recipe was better than its modified formula and cisapride.Conclusion Liangruntongluo Recipe can improve gastrointestinal dysfunction of DM rats.
