Result of 3-dimensional conformal radiotherapy combined with concurrent chemotherapy for postoperatively Ioco-regionally recurrent or mastastatic rectal cancer
- VernacularTitle:三维适形放疗同步化疗直肠癌术后局部复发或盆腔转移的疗效观察
- Author:
Zhenyu SHAO
;
Jiandong ZHANG
;
Jinming YU
;
Yan LI
;
Fengjun LIU
- Publication Type:Journal Article
- Keywords:
Neoplasm recurrence,local/radlotherapy;
Neoplasm metastasis,pelvic/radiotherapy;
Three-dimensional conformal;
Neoplasm recurrence,local/chemotherapy;
Neoplasm metastasis,pelvic/chemotherapy;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2008;17(5):358-360
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of three-dimensional conformal radiotherapy (3DCRT) combined with concurrent chemotherapy for loco-regionally recurrent or mastastatie rectal cancer. Methods Between June 2004 and January 2007,47 patients with loco-regionally recurrent or nmatastatic rectal cancer were treated by 3DCRT of 55-65 Gy in 1.8-2.0 Gy fractions. Chemotherapy was given concurrenfly using oxaliplatin(100 mg/m2 ,iv drop,d1 ) and capecitabine(1500 mg/m2,orally,dl-14,21 days per cycle). Results After the follow-up of 12-35 months, the total response rate, complete response rate and partial response rate were 79% (37/47) ,19% (9/47) and 60% (28/47) ,respectively. The pain-alleviation rate and the mean pain-alleviation time were 85% and 6 months. The 1- and 2-year survival rates were 83% and 51%. Quality of life was improved without any treatment related death. Conclusions 3DCRT combined with concurrent chemotherapy is effective and well-tolerated in patients with post-operatively locoregionally recurrent or mastastatic rectal cancer.
