Thyroid dysfunction induced by interferon α therapy in chronic hepatitis
- VernacularTitle:干扰素α治疗慢性肝炎诱发甲状腺功能异常的临床研究
- Author:
Yuejun PAN
;
Ruosu YING
;
Huimin FAN
;
Chunlan ZHANG
;
Xiaoping TANG
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis;
Interferon;
Thyroid dysfunction
- From:
Chinese Journal of Clinical Infectious Diseases
2008;1(3):153-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence and clinical characteristics of thyroid dysfunction induced by IFNα therapy in patients with chronic hepatitis.Methods Thyroid function of 310 patients with chronic hepatitis receiving IFNα therapy were evaluated.Results Serum free tri-iodothymnine (F13),free thyroxine(FT4)and sensitive thyroid-stimulating hormone(sTSH)of all patients were normal and TGAb was negative before IFNα therapy.After the treatment,10 patients(10/3 10,3.22%)had thyroid dysfunction,in which 7 were of hypothyroidism and 3 were of hyperthyroidism.The thyroid function of all patients recovered within 1-year follow-up.Conclusions IFNα therapy may induce thyroid dysfunction in patients with chronic hepatitis,in which prognosis can be good when appropriate treatment is given.
