Effects-of nuclear factor-kappa B in the progress of acute pancreatitis
- VernacularTitle:NF-κB在急性胰腺炎病程进展中的作用
- Author:
Tao JI
;
Zhinggang TANG
- Publication Type:Journal Article
- Keywords:
nuclear factor-kappa B;
acute pancreatitis;
cytokine;
apoptosis
- From:
International Journal of Surgery
2008;35(9):612-615
- CountryChina
- Language:Chinese
-
Abstract:
The cascade release of cytokine the critical aggravation factor for acute pancreatitis,induces the multi-ple organ dysfunction syndrome (MODS) and death at last. Nuclear factor-kappa B as a number of regulation of the nuclear factor can specific bind with a variety of gene promoter sites κB site, which cause inflammatory reaction, apoptosis, pathophysiologic reaction. The specific inhibitor of nuclear factor-kappa B can inhibit the activity of nu-clear factor-kappaB, inhibit the body's inflammatory response, and improve the prognosis of acute pancreatitis; it may be a potential target site for acute pancreatitis therapy. However, the other researches also found that inhibition of nuclear facter-κB could significantly increase the aggravation of acute pancreatitis. Accordingly, nuclear factor-kappa B research possess the important rank about the body's inflammatory respanse.
