Clinical and pathological analysis of 20 patients with pachydermodactly and follow-up of 6 patient
- VernacularTitle:厚皮指症20例临床病理分析及六例随访
- Author:
Dongfeng LIANG
;
Hua ZHAO
;
Chunhua YANG
;
Feng HUANG
;
Jianglin ZHANG
;
Min WEI
;
Dianjun WANG
- Publication Type:Journal Article
- Keywords:
Pathology;
Prognosis;
Pachydermodactyly
- From:
Chinese Journal of Rheumatology
2008;12(9):632-634
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the understanding of the clinical features, differential diagnosis and prognosis of pachydermodactyly. Methods The clinical data of 20 patients with pachydermo dactyly and follow-up data of 6 patient were analyzed. Results Seventeen out of 20 patients were male. The average onset age was (15±2) years. All of them had asymptomatic, firm swellings which developed insidiously on both sides of the proximal interphalangeal (PIP) joints. All the patients indicated that they were in the compulsive habit of interlacing their fingers and squeezing them. For all patients, biochemical examinations were normal and there was no rheumatoid factor or antinuclear antibodies. X-ray and MRI showed that the thickening of soft tissue around PIP joints without changes in bones or joints structure. Histopathologic findings from the swellings reveMed marked hyperkeratosis, with slight epidermal hyperplasia, and a markedly thickened dermis with whorled, densely aggregated bundles of coarse collagen. Even though 8 patients in the group had gotten rid of the aforesaid habit for 3 to 22 years, the swellings of their PIP joints did not resolve. Conclusion Pachy-dermodactyly is a benign digital fibromatosis which usually involves the PIP joints. It can be distinguished from juvenile rheumatoid arthritis and knuckle pad.
