Effect of Nimodipine Liposomes for Injection on Focal Cerebral Ischemia/Reperfusion Injury in Rats
- VernacularTitle:注射用尼莫地平脂质体对大鼠局灶性脑缺血再灌注损伤的影响
- Author:
Tianhua YAN
;
Juan YANG
;
Qiujuan WANG
;
Zhiwei PAN
;
Jiabi ZHU
- Publication Type:Journal Article
- Keywords:
nimodipine liposome;
cerebral ischemia;
reperfusion injury;
middle cerebral artery occlusion
- From:
International Journal of Cerebrovascular Diseases
2008;16(8):576-580
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of nimodipine liposomes for injection(NOLI)on focal cerebral ischemia/reperfusion(I/R)injury in rats.Methods:Seventy SD rats were divided into NDLI 1.00 mg/kg,NDLI 0.50 mg/kg,NDLI 0.25 mg/kg,nimodipine 1.00mg/kg,solvent 10 mL/kg,sham-operation and ischemic model groups.The model of middle cerelral artery occlusion in rat was replicated.The behavioral scores in rats were assessed in all groups.The infarct volume,brain water content,biochemical indices of brain homogenate and histology were detected.Results:1he NDLI 1.00mg/kg,0.50 mg/kg and 0.25 mg/kg groups could significantly improve the behavior scores in focal cerebral ischemic rats,reduce the volume of cerebral infarction,decrease the brain water content,improve the activities of Na+,K+-ATPase,Ca2+-ATPase,glutathione(GSH)and superoxide dismutazse(SOD)in brain tissues,reduce conteras of malondialdehyde(MDA),lactic acid(LA)and nitric oxide(NO),and improve histo logical injury.Conclusions:NDLI has the protective effect on focal cerebral ischemia/reperfusion injury in rats.
