Relationship between NF-kB and pancreatic cancer
- VernacularTitle:NF-κB与胰腺癌的关系研究进展
- Author:
Hongcheng WANG
;
Xinyu HUANG
- Publication Type:Journal Article
- Keywords:
pancreatic cancer;
NF-κB;
targeting therapy
- From:
International Journal of Surgery
2008;35(9):615-618
- CountryChina
- Language:Chinese
-
Abstract:
NF-κB is a nuclear transcription factor with multiple adjustion. The activation of NF-κB can occur by three different mechanisms. The multiple NF-κB activation pathways are important due to the large number of genes that are regulated by NF-κB and their effects on cancer cells. These gene products can promote growth and tumori-genesis, inhibit apoptosis, allow metastasis and invasion, promote angingenesis, and cause chemoresistance. All of these roles in pancreatic cancer make NF-κB a promising target in treatment. Therefore, inhibiting the activity of NF-κB becomes a hot spot and novel idea of preventing and treating pancreatic cancer.
