Anti-cyclic citrullinated peptide antibody in rheumatoid arthritis: relation with disease activity and bone erosion
- VernacularTitle:抗环瓜氨酸肽抗体与类风湿关节炎疾病活动及骨侵蚀关系的研究
- Author:
Hongqing NIU
;
Xiaofeng LI
;
Liyun ZHANG
;
Yani LIU
;
Jinli RU
;
Xuefang HU
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Anti-cyclic citrullinated peptide antibody;
Disease activity score28;
Health assessment questionnaire;
Bone erosion
- From:
Chinese Journal of Rheumatology
2008;12(9):603-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the correlation between anti-cyclic citrulinated peptide antibody (anti-CCP), rheumatoid factor (RF) and disease activity, functional capacity, bone erosion of rheumatoid arthritis (RA). Methods The correlation between anti-CCP, RF and disease activity score 28 (DAS28),health assessment questionnaire(HAQ) and bone erosion was assessed. Results Among the 218 RA patients,76% were anti-CCP-positive and 71% were RF-positive. The mean DAS28 score of RA patients with anti-CCP-positive and RF-positive was significantly higher than patients without anti-CCP and RF. The serum an-ti-CCP levels and RF levels showed a significant correlation with DAS28 score. However, the HAQ scores, ESR and CRP levels showed no significant difference between anti-CCP-positive and anti-CCP-negafive patients, RF-positive and RF-negative patients. Among anti-CCP-positive RA patients, the number of patients with erosive disease was significantly higher than patients without anti-CCP. However, the number of patients with erosive disease was not significantly different between RF-positive and RF-negative patients. Conclusion Anti-CCP and RF arc associated with disease activity. Anti-CCP is associated with bone erosion. No association is found between RF and bone erosion.
