Improvement of liver function of rats with obstructive jaundice by selective external biliary drainage
- VernacularTitle:选择性胆管外引流改善梗阻性黄疸大鼠肝功能的研究
- Author:
Yongyi ZENG
;
Shuguo ZHENG
;
Jiahong DONG
- Publication Type:Journal Article
- Keywords:
Obstructive jaundice;
Selective external biliary drainage;
Membrane transport protein;
Rat
- From:
Chinese Journal of Digestive Surgery
2008;7(5):356-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of selective external biliary drainage (SEBD) on the liver function of rats with obstructive jaundice. Methods The rates of right hepatic lobe weight against body weight of SD rats in SEBD group and total external biliary drainage (TEBD) group were calculated at day 0, 1, 4, 7, 10 after external biliary drainage. The mRNA and protein expressions of multidrug resistance-associated protein 2 (MRP2) and bile salt export pump (BSEP) were detected by RT-PCR and Western blot. Results Compared with TEBD group, the rate of right hepatic lobe weight against body weight and mRNA and protein expression of MRP2 and BSEP were significantly higher in SEBD group (t=15.569, P <0.05 ; t =4.485, 7.143, 9.169, 5.178, P <0.05). Conclusions SEBD improves the liver function of rats with obstructive jaundice, which may be related to the compensatory increase of remnant liver volume and elevation of expression per volume of membrane transport proteins.
