Reversion of multidrug resistance of hepatoma cell line SMMC-7721/ADM by adriamycin-loaded immuno-nanoparticles
- VernacularTitle:阿霉素免疫毫微粒对肝癌细胞多药耐药的逆转
- Author:
Heping KAN
;
Yongfa TAN
;
Yixiong LIN
;
Chunfang LI
;
Jie ZHOU
- Publication Type:Journal Article
- Keywords:
Liver cancer;
Adriamycin;
Immuno-nanoparticle;
Multidrug resistance
- From:
Chinese Journal of Digestive Surgery
2008;7(5):363-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of adriamycin-loaded immuno-nanoparticles on multidrug resistance (MDR) of hepatoma cell line SMMC-7721/ADM. Methods The cytotoxicity of the adriamycin-loaded immuno-nanoparticles on the bepatoma cell line SMMC-7721/ADM in vitro and the tumor cell-binding ability of adriamycin-loaded immuno-nanoparticles were detected. Results The effect of the cytotoxicity of adriamycin-loaded immuno-nanoparticles on the hepatoma cell line SMMC-7721/ADM was significantly better than that of adriamycin-loaded nanoparticles. Adriamycin-loaded immuno-nanoparticles had the specific binding ability with the hepatoma cell line SMMC-7721/ADM. Conclusions Adriamycin-loaded immuno-nanoparticles can overcome the MDR of the tumor in vitro. The mechanism may be that immuno-nanoparticles could adhere to the tumor cell membrane, and the release of the loaded adriamycin creates a high local concentration in the extracellular medium. The increased concentration gradient improves the diffusion of adriamycin from the extracellular medium to the intracellular medium.
