Association of morbid obesity,metabolic syndrome and polymorphism of β3-adrenergic receptor gene in the Hasake population in xinjiang
- VernacularTitle:β3肾上腺素能受体基因多态与新疆哈萨克族人腹型肥胖和代谢综合征的相关研究
- Author:
Yanying GUO
;
Huijuan PAN
;
Kun WANG
;
Lei ZHAO
;
Bingxian HE
- Publication Type:Journal Article
- Keywords:
Receptom,adrenergic,beta-3;
Polymorphism,genetic;
Obesity;
Metabolic syndrome X
- From:
Journal of Chinese Physician
2008;10(8):1069-1071
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genotype of Trp64Arg polymorphism of β3-adrenergic receptor gene and analyze the role ofβ3-adrenerglc receptor gene in the pathogenesis of morbid obesity and metabolic syndrome(MS).Methods PCR-restriction fragment length polymorphism Was used to detect the genotypes of 172 patients with MS,92 patient.with morbid obesity and 92 controls,and some biochemlcal indexes were detected.The association of the polymorohism with morbid obesity and MS Was assessed in case-control study.Resuits No statistically significant differences were found in the frequencies of Trp64Arg of β3-AR among the three groups.Conclusion Trp64Arg polymorphism of β3-AR was not significandy associated with morbid obesity and MS in the Hazak in xinjiang.
