Association study of cyclooxygenuse 2 polymorphisms and bladder cancer
- VernacularTitle:环氧合酶-2基因多态性与膀胱癌的易感性
- Author:
Dongkui SONG
;
Kun CHEN
;
Zhongxue LI
;
Liangbin LI
;
Xiaoming YANG
;
Jian LIU
;
Lirong ZHANG
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Carcinoma;
Cyclooxygenase-2;
Genetic polymorphisms
- From:
Chinese Journal of Urology
2008;29(10):704-707
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between cyclooxygenase 2 (COX-2) polymor phisms and the susceptibility of bladder cancer.Methods Polymerase chain reaction restricted frag ments length polymorphism (PCR-RFLP) and the primer introduced restriction analysis (PIRA-PCR)assay were used to genotype the COX-2-765G/C, 1195G/A and 8473T/C polymorphisms in a case control study of 180 bladder cancer cases and 180 cancer free controls in a Chinese population.Re stilts The distribution of the genotype frequencies of 765G/C and 1195G/A were not statisticallydifferent between the cases and controls (P=0.582 for-765G/C and P=0.270 for-1195G/A).Poly morphisms of COX 2-8473T/C were associated with the susceptibility to bladder cancer.The individ uals with the 8473C allele had a decreased risk of bladder cancer (OR=0.56,95% CI=0.35 0.88).Conclusions Polymorphisms of COX-2-765G/C and-1195G/A are not associated with the suscepti bility to bladder cancer.However,COX-2-8473T/C can reduce the risk of bladder cancer.
